Video games based on Fullmetal Alchemist have been released. The storylines of the games often diverge from those of the anime and manga, and feature original characters. Square Enix has released three role-playing games (RPG)—Fullmetal Alchemist and the Broken Angel, Curse of the Crimson Elixir, and Kami o Tsugu Shōjo. Bandai has released two RPG titles, Fullmetal Alchemist: Stray Rondo (鋼の錬金術師 迷走の輪舞曲 Hagane no Renkinjutsushi Meisō no Rondo?) and Fullmetal Alchemist: Sonata of Memory (鋼の錬金術師 想い出の奏鳴曲 Hagane no Renkinjutsushi Omoide no Sonata?), for the Game Boy Advance and one, Dual Sympathy, for the Nintendo DS. In Japan, Bandai released an RPG Fullmetal Alchemist: To the Promised Day (鋼の錬金術師 Fullmetal Alchemist 約束の日へ Hagane no Renkinjutsushi Fullmetal Alchemist Yakusoku no Hi e?) for the PlayStation Portable on May 20, 2010. Bandai also released a fighting game, Dream Carnival, for the PlayStation 2. Destineer released a game based on the trading card game in North America for the Nintendo DS. Of the seven games made in Japan, Broken Angel, Curse of the Crimson Elixir, and Dual Sympathy have seen international releases. For the Wii, Akatsuki no Ōji (暁の王子?, lit. Fullmetal Alchemist: Prince of the Dawn) was released in Japan on August 13, 2009. A direct sequel of the game, Tasogare no Shōjo (黄昏の少女?, lit. Fullmetal Alchemist: Daughter of the Dusk), was released on December 10, 2009, for the same console.
Funimation licensed the franchise to create a new series of Fullmetal Alchemist related video games to be published by Destineer Publishing Corporation in the United States. Destineer released its first Fullmetal Alchemist game for the Nintendo DS, a translation of Bandai's Dual Sympathy, on December 15, 2006, and said that they plan to release further titles. On February 19, 2007, Destineer announced the second game in its Fullmetal Alchemist series, the Fullmetal Alchemist Trading Card Game, which was released on October 15, 2007. A third game for the PlayStation Portable titled Fullmetal Alchemist: Senka wo Takuseshi Mono (背中を託せし者?) was released in Japan on October 15, 2009. A European release of the game, published by with Namco Bandai, was announced on March 4, 2010. The massively multiplayer online role-playing game MapleStory also received special in-game items based on the anime series.
Arakawa oversaw the story and designed the characters for the RPG games, while Bones—the studio responsible for the anime series—produced several animation sequences. The developers looked at other titles—specifically Square Enix's action role-playing game Kingdom Hearts and other games based on manga series, such as Dragon Ball, Naruto or One Piece games—for inspiration. The biggest challenge was to make a "full-fledged" game rather than a simple character-based one. Tomoya Asano, the assistant producer for the games, said that development took more than a year, unlike most character-based games.