Charlie Murder is a side-scrolling beat 'em up game with role-playing game elements. Players select one of five band members to play as; the lead vocalist and band namesake Charlie Murder, guitarist Lester Deth, bassist Tommy Homicide, backup vocalist Kelly "Skelekitten" Skitten, or drummer The Rexecutioner. Players can complete the game alone, or can team together with up to three other people, through either offline (with all of the players using the same Xbox 360) or online cooperative gameplay (co-op). With each additional player, the number of enemies that appear on screen at once increases. Players can also fight each other in special areas of the game. The game takes place across several different areas, including a construction site, a graveyard, a pirate ship, and a mall. Players are pitted against a large variety of enemies, including zombies, witches, ninjas, giant rats, yetis, and sharks with dynamite strapped to their heads. Interspersed between the normal combat levels are a number of minigames and special levels, including driving and flying levels. The game has a play time of around ten hours.