Takes place in the year 2028, a hundred years after the events of Blood. Caleb has spent the last century searching for a way to resurrect his comrades, The Chosen, killed in the previous game by the Cabal, a cult dedicated to the worship of the evil god, Tchernobog. The Cabal has spent the century since Tchernobog’s death by Caleb's hands turning the cult into a global mega-corporation called CabalCo, using its economic influence to control the world’s populace. Caleb must confront Gideon, the Cabal's current leader who has been raised to restore Tchernobog and destroy Caleb, now called the “Great Betrayer”. Game can be played as any of the four Chosen (Caleb, Ophelia, Gabriella, Ishmael) who each have strengths and weaknesses. However, only as Caleb can the player experience the storyline.